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H 1 Genetic variability under the seed bank coalescent

Auteurs : Blath, Jochen (Auteur de la Conférence)
CIRM (Editeur )

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    Résumé : We analyse patterns of genetic variability of populations in the presence of a large seed bank with the help of a new coalescent structure called seed bank coalescent. This ancestral process appears naturally as scaling limit of the genealogy of large populations that sustain seed banks, if the seed bank size and individual dormancy times are of the same order as the active population. Mutations appear as Poisson process on the active lineages, and potentially at reduced rate also on the dormant lineages. The presence of ‘dormant’ lineages leads to qualitatively altered times to the most recent common ancestor and non-classical patterns of genetic diversity. To illustrate this we provide a Wright-Fisher model with seed bank component and mutation, motivated from recent models of microbial dormancy, whose genealogy can be described by the seed bank coalescent. Based on our coalescent model, we derive recursions for the expectation and variance of the time to most recent common ancestor, number of segregating sites, pairwise differences, and singletons. Commonly employed distance statistics, in the presence and absence of a seed bank, are compared. The effect of a seed bank on the expected site-frequency spectrum is also investigated. Our results indicate that the presence of a large seed bank considerably alters the distribution of some distance statistics, as well as the site-frequency spectrum. Thus, one should be able to detect the presence of a large seed bank in genetic data. Joint work with Bjarki Eldon, Adrián González Casanova, Noemi Kurt, Maite Wilke-Berenguer

    Codes MSC :
    60K35 - Interacting random processes; statistical mechanics type models; percolation theory
    62P10 - Applications of statistics to biology and medical sciences
    92D10 - Genetics

      Informations sur la Vidéo

      Langue : Anglais
      Date de publication : 02/07/15
      Date de captation : 18/06/15
      Collection : Research talks ; Mathematics in Science and Technology ; Probability and Statistics
      Sous collection : Research talks
      Format : quicktime ; audio/x-aac
      Durée : 00:47:44
      Domaine : Probability & Statistics ; Mathematics in Science & Technology
      Audience : Chercheurs ; Doctorants , Post - Doctorants
      Download : https://videos.cirm-math.fr/2015-06-18_Blath.mp4

    Informations sur la rencontre

    Nom de la rencontre : Probability and biological evolution / Probabilités et évolution biologique
    Organisateurs de la rencontre : Pardoux, Etienne ; Wakolbinger, Anton
    Dates : 15/06/15 - 19/06/15
    Année de la rencontre : 2015
    URL Congrès : http://conferences.cirm-math.fr/1112.html

    Citation Data

    DOI : 10.24350/CIRM.V.18772903
    Cite this video as: Blath, Jochen (2015). Genetic variability under the seed bank coalescent. CIRM. Audiovisual resource. doi:10.24350/CIRM.V.18772903
    URI : http://dx.doi.org/10.24350/CIRM.V.18772903


    Bibliographie

    1. Blath, J., González Casanova, A., Eldon, B., Kurt, N. & Wilke-Berenguer, M. (2015). Genetic variability under the seedbank coalescent. Genetics, 115.176818 - http://dx.doi.org/10.1534/genetics.115.176818

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