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H 1 Genetic diversity in the interference selection limit

Auteurs : Desai, Michael (Auteur de la Conférence)
CIRM (Editeur )

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    Résumé : Pervasive natural selection can strongly influence observed patterns of genetic variation, but these effects remain poorly understood when multiple selected variants segregate in nearby regions of the genome. Classical population genetics fails to account for interference between linked mutations, which grows increasingly severe as the density of selected polymorphisms increases. I will describe a simple limit that emerges when interference is common, in which the fitness effects of individual mutations play a relatively minor role. Instead, similar to models of quantitative genetics, molecular evolution is determined by the variance in fitness within the population, defined over an effectively asexual segment of the genome (a "linkage block"). I will describe how we can exploit this insensitivity in a new "coarse-grained" coalescent framework, which approximates the effects of many weakly selected mutations with a smaller number of strongly selected mutations that create the same variance in fitness. This approximation generates accurate and efficient predictions for silent site variability when interference is common. However, these results suggest that there is reduced power to resolve individual selection pressures when interference is sufficiently widespread, since a broad range of parameters possess nearly identical patterns of silent site variability.

    Codes MSC :
    92D10 - Genetics
    92D15 - Problems related to evolution

      Informations sur la Vidéo

      Langue : Anglais
      Date de publication : 01/07/15
      Date de captation : 17/06/15
      Collection : Research talks ; Mathematics in Science and Technology ; Probability and Statistics
      Format : quicktime ; audio/x-aac
      Durée : 00:40:21
      Domaine : Mathematics in Science & Technology ; Probability & Statistics
      Audience : Chercheurs ; Doctorants , Post - Doctorants
      Download : https://videos.cirm-math.fr/2015-06-17_Desai.mp4

    Informations sur la rencontre

    Nom de la rencontre : Probability and biological evolution / Probabilités et évolution biologique
    Organisateurs de la rencontre : Pardoux, Etienne ; Wakolbinger, Anton
    Dates : 15/06/15 - 19/06/15
    Année de la rencontre : 2015
    URL Congrès : http://conferences.cirm-math.fr/1112.html

    Citation Data

    DOI : 10.24350/CIRM.V.18773503
    Cite this video as: Desai, Michael (2015). Genetic diversity in the interference selection limit. CIRM. Audiovisual resource. doi:10.24350/CIRM.V.18773503
    URI : http://dx.doi.org/10.24350/CIRM.V.18773503


    Bibliographie

    1. Good, B.H., Walczak, A.M., Neher, R.A., & Desai, M.M. (2014). Genetic Diversity in the Interference Selection Limit. PLoS Genetics, 10(3): e1004222 - http://dx.doi.org/10.1371/journal.pgen.1004222

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