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We present a novel methodology for causal inference based on an invariance principle. It exploits the advantage of heterogeneity in larger datasets, arising from different experimental conditions (i.e. an aspect of "Big Data"). Despite fundamental identifiability issues, the method comes with statistical confidence statements leading to more reliable results than alternative procedures based on graphical modeling. We also discuss applications in biology, in particular for large-scale gene knock-down experiments in yeast where computational and statistical methods have an interesting potential for prediction and prioritization of new experimental interventions. We present a novel methodology for causal inference based on an invariance principle. It exploits the advantage of heterogeneity in larger datasets, arising from different experimental conditions (i.e. an aspect of "Big Data"). Despite fundamental identifiability issues, the method comes with statistical confidence statements leading to more reliable results than alternative procedures based on graphical modeling. We also discuss applications in ...

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Documents 62Pxx | enregistrements trouvés : 54

The power of heterogeneous large-scale data for high-dimensional causal inference Bühlmann, Peter | CIRM H Nouveau

Statistique industriejournees statistique tenu au centre international de rencontres mathematiques, marseille,28-30 jan.,1985 | C.I.Rm.-S.M.F. 1985 Nouveau

Probability theory and mathematical statistics with applicationsProceedings of the 5th Pannonian symposium on mathematical statistics,Visegrad,Hungary,20-24 May,1985 | Akademiai Kiado 1988 Nouveau

Reliability and fault tree analysistheoretical and applied aspects of system reliability and safety assessmentconference on... held at the University of CaliforniaSept. 3-7 Barlow,Richard E. ; Fussell,Jerry B. ; Singpurwalla , Nozer D. | SIAM 1975 Nouveau

Inférence non paramétriqueles statistiques de rangsjournées d'étude en statistique organisées par l'ASUOct. Droesbeke, Jean-Jacques ; Fine, Jeanne | Editions Ellipses;Editions De L'Universite De Bruxelles 1996 Nouveau

Maximum-entropy and bayesian spectral analysis and estimation problems :proceedings fo the third workshop on...#Aug. 1-4 Erickson, Gary J. ; Smith, C. Ray | D. Reidel Publishing Company 1987 Nouveau

A modern course on statistical distributions in scientific work,vol. 2proceedings of the nato advanced institute held at the university of calgary,a lberta,canada july 29 - august 10,1974 Kotz, S. ; Ord, J. K. ; Patil, G. P. | D. Reidel Publisher Co. 1975 Nouveau

Applications of statisticsproceedings of the symposium held at Wright State University,Dayton,Ohio,14-18 june,1976 Krishnaiah, Paruchuri R. | North-Holland Publishing Co. 1977 Nouveau

Multidimensional mathematical demographypapers presented at the conference on... held at the university of Maryland, College Park,march 23-25,1981 Land, Kenneth C. ; Rogers, Andrei | Academic Press 1982 Nouveau

Statistics at universities :its impact for society#workshop May 22-23 Zempléni, Andras | Eötvös University Press 1997 Nouveau

Studies in econometrics, time series, and multivariate statistics :in commemoration of T.W. and Erson's 65 th birthday, includes bibliographical references Amemiya, Takeshi ; Goodman, Leo A. ; Karlin, Samuel | Academic Press 1983 Nouveau

An introduction to multivariate statistical analysis Anderson, T. W. | John Wiley And Sons 1984 Nouveau

The skew-normal and related families Azzalini, Adelchi ; Capitanio, Antonella | Cambridge University Press 2014 Nouveau

Le jeu la chance et le hasard Bachelier, Louis | Editions Jacques Gabay 1993 Nouveau

La chance et les jeux de hasard Boll, Marcel | Editions Jacques Gabay 1992 Nouveau

Meta-analysis:a structural equation modeling approach Cheung, Mike W.-L. | Wiley 2015 Nouveau

Mathematical statistics with resampling and R Chihara, Laura ; Hesterberg, Tim | John Wiley & Sons, Inc. 2011 Nouveau

Statistics and data with R:an applied approach through examples Cohen, Yosef ; Cohen, Jeremiah Y. | John Wiley & Sons, LTD 2008 Nouveau

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Statistique industrie
journees statistique tenu au centre international de rencontres mathematiques, marseille,28-30 jan.,1985 | C.I.Rm.-S.M.F. 1985 Nouveau

Probability theory and mathematical statistics with applications
Proceedings of the 5th Pannonian symposium on mathematical statistics,Visegrad,Hungary,20-24 May,1985 | Akademiai Kiado 1988 Nouveau

Reliability and fault tree analysis
theoretical and applied aspects of system reliability and safety assessment
conference on... held at the University of California
Sept. 3-7 Barlow,Richard E. ; Fussell,Jerry B. ; Singpurwalla , Nozer D. | SIAM 1975 Nouveau

Inférence non paramétrique
les statistiques de rangs
journées d'étude en statistique organisées par l'ASU
Oct. Droesbeke, Jean-Jacques ; Fine, Jeanne | Editions Ellipses;Editions De L'Universite De Bruxelles 1996 Nouveau

Maximum-entropy and bayesian spectral analysis and estimation problems :
proceedings fo the third workshop on...#Aug. 1-4 Erickson, Gary J. ; Smith, C. Ray | D. Reidel Publishing Company 1987 Nouveau

A modern course on statistical distributions in scientific work,vol. 2
proceedings of the nato advanced institute held at the university of calgary,a lberta,canada july 29 - august 10,1974 Kotz, S. ; Ord, J. K. ; Patil, G. P. | D. Reidel Publisher Co. 1975 Nouveau

Applications of statistics
proceedings of the symposium held at Wright State University,Dayton,Ohio,14-18 june,1976 Krishnaiah, Paruchuri R. | North-Holland Publishing Co. 1977 Nouveau

Multidimensional mathematical demography
papers presented at the conference on... held at the university of Maryland, College Park,march 23-25,1981 Land, Kenneth C. ; Rogers, Andrei | Academic Press 1982 Nouveau

Statistics at universities :
its impact for society#workshop May 22-23 Zempléni, Andras | Eötvös University Press 1997 Nouveau

Studies in econometrics, time series, and multivariate statistics :
in commemoration of T.W. and Erson's 65 th birthday, includes bibliographical references Amemiya, Takeshi ; Goodman, Leo A. ; Karlin, Samuel | Academic Press 1983 Nouveau

Meta-analysis:
a structural equation modeling approach Cheung, Mike W.-L. | Wiley 2015 Nouveau

Statistics and data with R:
an applied approach through examples Cohen, Yosef ; Cohen, Jeremiah Y. | John Wiley & Sons, LTD 2008 Nouveau