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We present a novel methodology for causal inference based on an invariance principle. It exploits the advantage of heterogeneity in larger datasets, arising from different experimental conditions (i.e. an aspect of "Big Data"). Despite fundamental identifiability issues, the method comes with statistical confidence statements leading to more reliable results than alternative procedures based on graphical modeling. We also discuss applications in biology, in particular for large-scale gene knock-down experiments in yeast where computational and statistical methods have an interesting potential for prediction and prioritization of new experimental interventions. We present a novel methodology for causal inference based on an invariance principle. It exploits the advantage of heterogeneity in larger datasets, arising from different experimental conditions (i.e. an aspect of "Big Data"). Despite fundamental identifiability issues, the method comes with statistical confidence statements leading to more reliable results than alternative procedures based on graphical modeling. We also discuss applications in ...

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Documents 62Fxx | enregistrements trouvés : 67

The power of heterogeneous large-scale data for high-dimensional causal inference Bühlmann, Peter | CIRM H Nouveau

Bayesian statistics 5proceedings of the fifth Valencia international meeting on... held at the Hotel Melia June 5-9 Berger, James O. ; Bernardo, J. M. ; Dawid, A. P. | Clarendon Press 1996 Nouveau

Statistical decision theory and related topics III. Vol. 2the third Purdue symposium on...held at Purdue UniversityJune 1-5 Berger, James O. ; Gupta, Shanti S. | Academic Press 1982 Nouveau

Statistcal decision theory and related topics III. Vol. 1the third Purdue symposium on...held at Purdue UniversityJune 1-5 Berger, James O. ; Gupta, Shanti S. | Academic Press 1982 Nouveau

Bayesian statistics 2proceedings of the second valencia international meeting,sept. 6-10,1983 Bernardo, J. M. ; Degroot, M. H. ; Lindley, D. V. | North-Holland;Valencia University Press 1985 Nouveau

Linear statistical inferenceproceedings of the international conference on... held at poznan,poland,june 4-8,1984 Calinski, T. ; Klonecki, W. | Springer-Verlag 1985 Nouveau

Actas del cuarto congreso Dr. Antonio A. R. Monteiro Departemento de Matematica | Departamento de Matematica ( UNS );Instituto de Matematica ( CONICET ) 1997 Nouveau

Analyse statistique des durees de vie,modelisation des donnees censureesjournées d'étude en statistique tenu au C.I.R.M.LuminyOctobre Droesbeke, Jean-Jacques ; Fichet, Bernard ; Tassi, Philippe | Economica 1989 Nouveau

Séries chronologiques, théorie en pratique des modèles arimajournées d'étude en statistiqueC.I.R.M.LuminyOct. Droesbeke, Jean-Jacques ; Fichet, Bernard ; Tassi, Phillipe | Economica 1989 Nouveau

Theoretical problems in mathematical statistics Linnik, Ju. V. | American Mathematical Society 1972 Nouveau

Foundations of statistical inferencea series of symposia was held at the university of western OntarioLondonCanadato celebrate the 70th birthday of professor V.M. JoshiMay 27-31 MacNeill, Ian B. ; Umphrey, Gary J. | D. Reidel Publisher Co. 1987 Nouveau

Goodness-of-fitorganisation of the ...,held in debrecen,hungary,june 25-29,1984 Revesz, P. ; Sarkadi, K. ; Sen, P. K. | North-Holland Publishing Co. 1987 Nouveau

Athens conference on applied probability and time series analysis Volume II E. J. Hannana conference was held March 22-26, 1995 at the Hotel Titania in Athens, Greece partly in memory of Ted Hannan Robinson, P. M. ; Rosenblatt, M. | Springer-Verlag 1996 Nouveau

Nonparametric functional estimation and related topicsproceedings of the NATO advanced study institute on nonparametric functional estimation and related topics, Spetses, Greece, July 29-August 10, 1990 Roussas, George | Kluwer Academic Publishers 1991 Nouveau

Optimizing methods in statistics :proceedings of a symposium held at the center for tomorrow,the ohio state university#June 14 -16,1971 Rustagi, Jagdish S. | Academic Press 1971 Nouveau

Statistical inference under order restrictions :the theory and application of isotonic regression Barlow,Richard E. ; Bartholomew, D. J. ; Bremner, J. M. ; Brunk, H. D. | John Wiley And Sons 1972 Nouveau

Outliers in statistical data Barnett, Vic ; Lewis, Toby | John Wiley And Sons 1995 Nouveau

La probabilité et l'évaluation des risques Bessis, J. | Masson 1984 Nouveau

Probability and statistics Blum, Julius R. ; Rosenblatt, Judah I. | W. B. Saunders Co. 1972 Nouveau

Fundamentals of statistical exponential familieswith applications in statistical decision theory Brown, Lawrence D. | Institute of Mathematical Statistics 1986 Nouveau

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Bayesian statistics 5
proceedings of the fifth Valencia international meeting on... held at the Hotel Melia
June 5-9 Berger, James O. ; Bernardo, J. M. ; Dawid, A. P. | Clarendon Press 1996 Nouveau

Statistical decision theory and related topics III. Vol. 2
the third Purdue symposium on...
held at Purdue University
June 1-5 Berger, James O. ; Gupta, Shanti S. | Academic Press 1982 Nouveau

Statistcal decision theory and related topics III. Vol. 1
the third Purdue symposium on...
held at Purdue University
June 1-5 Berger, James O. ; Gupta, Shanti S. | Academic Press 1982 Nouveau

Bayesian statistics 2
proceedings of the second valencia international meeting,sept. 6-10,1983 Bernardo, J. M. ; Degroot, M. H. ; Lindley, D. V. | North-Holland;Valencia University Press 1985 Nouveau

Linear statistical inference
proceedings of the international conference on... held at poznan,poland,june 4-8,1984 Calinski, T. ; Klonecki, W. | Springer-Verlag 1985 Nouveau

Analyse statistique des durees de vie,modelisation des donnees censurees
journées d'étude en statistique tenu au C.I.R.M.
Luminy
Octobre Droesbeke, Jean-Jacques ; Fichet, Bernard ; Tassi, Philippe | Economica 1989 Nouveau

Séries chronologiques, théorie en pratique des modèles arima
journées d'étude en statistique
C.I.R.M.
Luminy
Oct. Droesbeke, Jean-Jacques ; Fichet, Bernard ; Tassi, Phillipe | Economica 1989 Nouveau

Foundations of statistical inference
a series of symposia was held at the university of western Ontario
London
Canada
to celebrate the 70th birthday of professor V.M. Joshi
May 27-31 MacNeill, Ian B. ; Umphrey, Gary J. | D. Reidel Publisher Co. 1987 Nouveau

Goodness-of-fit
organisation of the ...,held in debrecen,hungary,june 25-29,1984 Revesz, P. ; Sarkadi, K. ; Sen, P. K. | North-Holland Publishing Co. 1987 Nouveau

Athens conference on applied probability and time series analysis Volume II E. J. Hannan
a conference was held March 22-26, 1995 at the Hotel Titania in Athens, Greece partly in memory of Ted Hannan Robinson, P. M. ; Rosenblatt, M. | Springer-Verlag 1996 Nouveau

Nonparametric functional estimation and related topics
proceedings of the NATO advanced study institute on nonparametric functional estimation and related topics, Spetses, Greece, July 29-August 10, 1990 Roussas, George | Kluwer Academic Publishers 1991 Nouveau

Optimizing methods in statistics :
proceedings of a symposium held at the center for tomorrow,the ohio state university#June 14 -16,1971 Rustagi, Jagdish S. | Academic Press 1971 Nouveau

Statistical inference under order restrictions :
the theory and application of isotonic regression Barlow,Richard E. ; Bartholomew, D. J. ; Bremner, J. M. ; Brunk, H. D. | John Wiley And Sons 1972 Nouveau

Fundamentals of statistical exponential families
with applications in statistical decision theory Brown, Lawrence D. | Institute of Mathematical Statistics 1986 Nouveau